Single Pass Cleanrooms
Once-through (non-recirculating) cleanrooms—softwall or hybrid systems for rapid, compliant containment.
Key Applications
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Hazardous drug handling & compounding (USP <800>)
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Cytotoxic prep and chemo staging (negative pressure)
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Powder weighing, sampling & dispensing
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Battery, nanomaterials, and reactive chemistries
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3D printing/resins and solvent processes
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Temporary clean zones, pilots, and tool isolation
Single pass is a term that simply means the air entering the cleanroom does not recirculate. While there are certainly examples of hardwall cleanrooms, seamless, or otherwise may need a single pass air flow design for hazardous drugs – typically we refer to single pass cleanrooms to describe softwall cleanrooms and rooms similar in design. Softwall cleanrooms are typically constructed of a steel or aluminum framework with a self-supporting ceiling system to support HEPA fan filter modules. However, there are examples of single pass systems that offer hard and semi-hard wall panels that may provide real differential pressure if needed. Talk to one of our experts today to learn more!
Why Ultrapure
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500+ projects delivered across regulated industries
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Modular systems that reduce build time and simplify future changes
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National installation network and experienced project management
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Engineer-led scoping to get airflow, pressure cascades, and cleaning protocols right the first time
Benefits
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Better containment: 100% once-through; no recirculation risk.
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Fast deployment: Modular frames with drop-in HEPA FFUs.
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Flexible envelopes: Softwall, semi-hard, or hardwall options.
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Simple HVAC tie-in: Direct exhaust to outside; minimal return.
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Pressure control: Supports negative/positive rooms as needed.
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Easy maintenance: Room-side replaceable filters; quick curtain/panel swaps.
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Scalable: Add bays/FFUs and extend frames as you grow.
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Cost-efficient build: Lower complexity vs full recirculating systems.
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